Warfarin Interaction With Hepatic Cytochrome P-450 Enzyme-Inducing Anticonvulsants
نویسندگان
چکیده
منابع مشابه
Cytochrome P-450 associated with free hepatic polyribosomes.
As is well known, administration of phenobarbital to rabbits and other animals causes proliferation of hepatic endoplasmic reticulum and sharp increases in concentrations of enzymes which metabolize phenobarbital and other xenobiotics by the mixed function oxidase process (1 -4). The mechanisms for induction of membranal proliferation and for increases in enzyme concentrations are unknown. Acco...
متن کاملInteraction of modified cyclodextrins with cytochrome P-450.
The effects of modified cyclodextrins (CDs) hydroxypropyl-beta-CD and methyl-beta-CD were studied in vitro on cDNA-expressed human cytochrome P-450 (CYP) activities (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4). The modified CDs inhibited the activities of CYP2C19 and CYP3A4 while enhancing CYP2C9 activity by 140 to 176% relative to the control values at lower concentrations. In addition, methy...
متن کاملPhospholipid requirement for dimethylnitrosamine demethylation by hamster hepatic microsomal cytochrome P-450 enzyme system.
Extraction with butan-1-ol of freeze-dried microsomal fractions from livers of 3-methyl-cholarthrene-pre-treated hamsters removed about 90% of the total lipid content, but the lipid remaining proved sufficient for the cytochrome P-450 enzyme system to retain about 15-40% of its original catalytic activity for dimethylnitrosamine demethylation. Addition of butan-1-ol-extracted total phospholipid...
متن کاملZonation of hepatic cytochrome P-450 expression and regulation.
The CYP genes encode enzymes of the cytochrome P-450 superfamily. Cytochrome P-450 (CYP) enzymes are expressed mainly in the liver and are active in mono-oxygenation and hydroxylation of various xenobiotics, including drugs and alcohols, as well as that of endogenous compounds such as steroids, bile acids, prostaglandins, leukotrienes and biogenic amines. In the liver the CYP enzymes are consti...
متن کاملThe role of hepatic cytochrome P-450 in sepsis.
Severe sepsis is a common, expensive, and fatal condition with as many deaths annually as those from acute myocardial infarctions. The average cost per case seems to exceed $22,000. The increased morbidity and mortality attributed to sepsis could be due to the lack of our understanding of mediators and factors responsible for early cellular alterations and thus could not be intervened which res...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical and Applied Thrombosis/Hemostasis
سال: 2017
ISSN: 1076-0296,1938-2723
DOI: 10.1177/1076029616687849